Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo

In order to enable ¹⁸F- and ¹⁷⁷Lu-labelling within the same molecule, we introduced a silicon-based fluoride acceptor (SiFA) into the hexa-D-glutamate chain of DOTA-PP-F11N. In addition, minigastrin analogues with a prolonged as well as <i>γ</i>-linked D-glutamate chain were sy...

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Detalhes bibliográficos

Principais autores:	Nadine Holzleitner, Thomas Günther, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Pharmaceuticals
Assuntos:	cholecystokinin-2 receptor (CCK-2R) cholecystokinin-B receptor (CCK-BR) medullary thyroid cancer (MTC) minigastrin analogues radiohybrid rhCCK
Acesso em linha:	https://www.mdpi.com/1424-8247/15/12/1467
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