Development of the First ¹⁸F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (<i>R</i>)-DOTAGA by DOTA in (<i>R</i>)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biodistribution and <i>µ</i>...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Thomas Günther, Nadine Holzleitner, Daniel Di Carlo, Nicole Urtz-Urban, Constantin Lapa, Hans-Jürgen Wester
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-03-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	cholecystokinin-2 receptor (CCK-2R) cholecystokinin-B receptor (CCK-BR) MTC <sup>18</sup>F-labeled minigastrin analogs radiohybrid rhCCK
Online-Zugang:	https://www.mdpi.com/1999-4923/15/3/826
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