Splenomegaly in de novo acute myeloid leukemia is associated with ASXL1 mutations together with a distinct clinical and gene expression profile

Abstract Background Splenomegaly is an event occurring in a variable range between 10–40% of de novo acute myeloid leukemia (AML), recently linked to poorer prognosis. Studies in murine models have shown that loss of the additional sex combs-like 1 (ASXL1) gene function leads to a significantly enla...

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Glavni autori:	Francesco Tarantini, Nicoletta Coccaro, Cosimo Cumbo, Immacolata Redavid, Luisa Anelli, Antonella Zagaria, Elisa Parciante, Maria Rosa Conserva, Giuseppina Tota, Crescenzio Francesco Minervini, Angela Minervini, Mariano Francesco Caratozzolo, Flaviana Marzano, Claudia Telegrafo, Bachir Balech, Anna Mestice, Vito Pier Gagliardi, Mario Delia, Paola Carluccio, Maria Giovanna Macchia, Apollonia Tullo, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-10-01
Serija:	Biomarker Research
Teme:	Acute myeloid leukemia Splenomegaly ASXL1 PCDHB2 LURAP1L/LURAP1L-AS1
Online pristup:	https://doi.org/10.1186/s40364-025-00833-8
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