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Case report: biallelic DNMT3A mutations in acute myeloid leukemia

DNMT3A gene mutations, detected in 20-25% of de novo acute myeloid leukemia (AML) patients, are typically heterozygous. Biallelic variants are uncommon, affecting ~3% of cases and identifying a worse prognosis. Indeed, two concomitant DNMT3A mutations were recently associated with shorter event-free...

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Enregistré dans:
Auteurs principaux: Cosimo Cumbo, Paola Orsini, Luisa Anelli, Antonella Zagaria, Maria Federica Iannò, Loris De Cecco, Crescenzio Francesco Minervini, Nicoletta Coccaro, Giuseppina Tota, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Francesco Tarantini, Angela Minervini, Paola Carluccio, Anna De Grassi, Ciro Leonardo Pierri, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2023-06-01
Collection:Frontiers in Oncology
Sujets:
DNMT3A
biallelic mutations
acute myeloid leukemia
hypermethylation
cell differentiation
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fonc.2023.1205220/full
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