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The CMV-Specific CD8<sup>+</sup> T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

Evolutionary processes govern the selection of T cell clonotypes that are optimally suited to mediate efficient antigen-specific immune responses against pathogens and tumors. While the theoretical diversity of T cell receptor (TCR) sequences is vast, the antigen-specific TCR repertoire is restricte...

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Principais autores: Kilian Schober, Pim Fuchs, Jonas Mir, Monika Hammel, Lorenzo Fanchi, Michael Flossdorf, Dirk H. Busch
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-08-01
coleção:Pathogens
Assuntos:
memory inflation
public clonotypes
generation probability
T cell response
TCR
convergent recombination
Acesso em linha:https://www.mdpi.com/2076-0817/9/8/650
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