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Microglial HDAC3 inhibits the migration of CD8-positive T cell in the development of EAE by restraining the expression of CCL5

Abstract Background Multiple sclerosis (MS) is a central nervous system disease caused by auto-immune reaction induced demyelination, however, the molecular mechanism of MS remains unclear. Previous study revealed that histone deacetylase 3 (HDAC3) is upregulated in the spinal cord of MS patient. He...

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Autors principals: Na Che, Yang Zhang, Bo Wang, Hongxing Wu, Zhiqiong Mao, Zengqiang Yuan, Xiangxi Kong, Yajin Liao
Format: Artigo
Idioma:Inglês
Publicat: BMC 2026-03-01
Col·lecció:Cell & Bioscience
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Accés en línia:https://doi.org/10.1186/s13578-026-01564-5
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