Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs

One of the major concerns for all in vivo experiments is intra- and inter-subject variability, which can be a great source of inaccuracy. The aim of this study is, therefore, to estimate the ability of parallel vs. cross-over design studies in order to describe the relative pharmacokinetic performan...

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Autors principals:	Jana Královičová, Aleš Bartůněk, Jiří Hofmann, Tomáš Křížek, Petr Kozlík, Jaroslava Roušarová, Pavel Ryšánek, Martin Šíma, Ondřej Slanař
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-03-01
Col·lecció:	Pharmaceutics
Matèries:	abiraterone variability pharmacokinetics cross-over design rat in vivo study
Accés en línia:	https://www.mdpi.com/1999-4923/14/3/643
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