Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation.
A critical step in X-chromosome inactivation (XCI), which results in the dosage compensation of X-linked gene expression in mammals, is the coating of the presumptive inactive X chromosome by the large noncoding Xist RNA, which then leads to the recruitment of other factors essential for the heteroc...
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| Автори: | , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Public Library of Science (PLoS)
2006-06-01
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| Серія: | PLoS Genetics |
| Онлайн доступ: | http://europepmc.org/articles/PMC1479048?pdf=render |
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