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HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

<p>Abstract</p> <p>Background</p> <p>Lens epithelium–derived growth factor (LEDGF/p75) is a cellular co-factor of HIV-1 integrase (IN) that tethers the viral pre-integration complex to the host cell chromatin and determines the genome wide integration site distribution pattern of HIV-1. Recently, we...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Schrijvers Rik, Vets Sofie, De Rijck Jan, Malani Nirav, Bushman Frederic D, Debyser Zeger, Gijsbers Rik
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2012-10-01
Rangatū:Retrovirology
Ngā marau:
Urunga tuihono:http://www.retrovirology.com/content/9/1/84
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