HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells
<p>Abstract</p> <p>Background</p> <p>Lens epithelium–derived growth factor (LEDGF/p75) is a cellular co-factor of HIV-1 integrase (IN) that tethers the viral pre-integration complex to the host cell chromatin and determines the genome wide integration site distribution pattern of HIV-1. Recently, we...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2012-10-01
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| Schriftenreihe: | Retrovirology |
| Schlagworte: | |
| Online-Zugang: | http://www.retrovirology.com/content/9/1/84 |
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