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Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium

Abstract Background Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here we used adult stem cell-derived cell cultures (or...

Celý popis

Uloženo v:
Hlavní autoři: Dora Angyal, Tessa A. Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R. de Jonge, Marcel J. C. Bijvelds
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-01-01
Edice:Cellular & Molecular Biology Letters
Témata:
CFTR
Cystic fibrosis
Cytokines
Epithelial ion transport
Organoid
Pancreatitis
On-line přístup:https://doi.org/10.1186/s11658-024-00537-1
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