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Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission

ABSTRACT Simian immunodeficiency viruses (SIVs) have crossed from apes to humans at least four times, but only one event gave rise to the AIDS pandemic. The host barriers that pandemic HIV-1 group M (major) strains overcame to spread efficiently in humans remain poorly understood. To identify such b...

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Wedi'i Gadw mewn:
Prif Awduron: Qinya Xie, Qingxing Wang, Sabrina Noettger, Guillermo Gosálbez, Annika C. Betzler, Meta Volcic, Dorota Kmiec, Stefan Krebs, Alexander Graf, Dila Gülensoy, Gilbert Weidinger, Konstantin M. J. Sparrer, Frank Kirchhoff
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2026-06-01
Cyfres:Journal of Virology
Pynciau:
SIVcpz
replication-competent CRISPR screen
IFITM2
PCED1B
MEFV
AXIN1
Mynediad Ar-lein:https://journals.asm.org/doi/10.1128/jvi.00314-26
Tagiau: Ychwanegu Tag
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