Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission

ABSTRACT Simian immunodeficiency viruses (SIVs) have crossed from apes to humans at least four times, but only one event gave rise to the AIDS pandemic. The host barriers that pandemic HIV-1 group M (major) strains overcame to spread efficiently in humans remain poorly understood. To identify such b...

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Bibliografski detalji

Glavni autori:	Qinya Xie, Qingxing Wang, Sabrina Noettger, Guillermo Gosálbez, Annika C. Betzler, Meta Volcic, Dorota Kmiec, Stefan Krebs, Alexander Graf, Dila Gülensoy, Gilbert Weidinger, Konstantin M. J. Sparrer, Frank Kirchhoff
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2026-06-01
Serija:	Journal of Virology
Teme:	SIVcpz replication-competent CRISPR screen IFITM2 PCED1B MEFV AXIN1
Online pristup:	https://journals.asm.org/doi/10.1128/jvi.00314-26
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