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An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities

Abstract Background Tumor-targeting IgE antibodies have elicited potent tumor-restricting effects by recruiting immune effector mechanisms. However, a dedicated platform for the generation, selection and evaluation of novel IgEs based on target antigen recognition and functional profiles has not bee...

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Bibliografiske detaljer
Principais autores: Lais C. G. F. Palhares, Melanie Grandits, Katie Stoker, Jitesh Chauhan, Heng Sheng Sow, Gilbert O. Fruhwirth, Sophia Tsoka, James Birtley, Leanne Partington, Tim Wilson, Elizabeth Hardaker, Sophia N. Karagiannis, Heather J. Bax, Kevin FitzGerald
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-02-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Online adgang:https://doi.org/10.1186/s13046-025-03319-5
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