An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities

Abstract Background Tumor-targeting IgE antibodies have elicited potent tumor-restricting effects by recruiting immune effector mechanisms. However, a dedicated platform for the generation, selection and evaluation of novel IgEs based on target antigen recognition and functional profiles has not bee...

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Autors principals:	Lais C. G. F. Palhares, Melanie Grandits, Katie Stoker, Jitesh Chauhan, Heng Sheng Sow, Gilbert O. Fruhwirth, Sophia Tsoka, James Birtley, Leanne Partington, Tim Wilson, Elizabeth Hardaker, Sophia N. Karagiannis, Heather J. Bax, Kevin FitzGerald
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-02-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	Breast Cancer HER2 IgE Immunotherapy
Accés en línia:	https://doi.org/10.1186/s13046-025-03319-5
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