Analysis of follow-up data in large biobank cohorts: a review of methodology

This study focuses on key methodological challenges in genome-wide association studies (GWAS) of biobank data with time-to-event outcomes, analyzed using the Cox proportional hazards (CPH) model. We address four primary issues: left-truncation of the data, computational inefficiency of standard mode...

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Bibliografiska uppgifter

Huvudupphov:	Anastassia Kolde, Merli Koitmäe, Meelis Käärik, Märt Möls, Krista Fischer
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2025-06-01
Serie:	Frontiers in Genetics
Ämnen:	survival analysis genome-wide association study populationbased biobank data martingale residuals cox proportional hazards model
Länkar:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1534726/full
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