Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Abstract Background Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electron...

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Autors principals:	Silva Kasela, Laura Birgit Luitva, Kristi Krebs, Estonian Biobank Research Team, Märt Möls, Lili Milani, Maris Alver
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-07-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Real-world health data Electronic Health Records Biobank Medication dosing Pharmacogenomics Genome-wide association study
Accés en línia:	https://doi.org/10.1186/s12967-025-06782-y
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