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Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Abstract Background Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electron...

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Principais autores: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, Estonian Biobank Research Team, Märt Möls, Lili Milani, Maris Alver
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-07-01
Serier:Journal of Translational Medicine
Fag:
Real-world health data
Electronic Health Records
Biobank
Medication dosing
Pharmacogenomics
Genome-wide association study
Online adgang:https://doi.org/10.1186/s12967-025-06782-y
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