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Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Abstract Background Neuroinflammation plays a critical role in the onset and development of neurodegeneration disorders such as Parkinson’s disease. The immune activities of the central nervous system are profoundly affected by peripheral immune activities. Immune tolerance refers to the unresponsiv...

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Principais autores: Yang Liu, Xin Xie, Li-Ping Xia, Hong Lv, Fan Lou, Yan Ren, Zhi-Yi He, Xiao-Guang Luo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-11-01
Serier:Journal of Neuroinflammation
Fag:
Microglia
Peripheral blood monocytes
Neuroinflammation
Neuroprotection
Neurodegeneration disease
Online adgang:http://link.springer.com/article/10.1186/s12974-017-0994-3
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