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SHP2 in microglia attenuates neuroinflammation and cognitive deficits in vascular dementia by modulating the FAK/Src/PU. 1/IRF8 pathway

Abstract Background Vascular dementia is a common cognitive disorder that is often triggered by neuroinflammatory responses caused by cerebrovascular injury, which further exacerbates the progression of the disease. Microglia play an important role in neuroinflammation, and the signalling pathway wi...

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Principais autores: Yanli Jia, Yanyan Ren, Yunmei Yu, Fangming Dong, Minxia Geng, Rongfang Feng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:European Journal of Medical Research
Fag:
Vascular dementia
Microglia
SHP2
FAK/Src/PU. 1/IRF8 pathway
Neuroinflammation
Online adgang:https://doi.org/10.1186/s40001-026-04317-9
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