Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

Abstract Background 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory...

Cijeli opis

Bibliografski detalji

Glavni autori:	Yu-Ping Shen, Lai San Fong, Zhi-Bo Yan, Jian-Zhong Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2019-04-01
Serija:	Biotechnology for Biofuels
Teme:	4-Hydroxyphenylacetic acid Directed evolution Dynamic pathway regulation Quorum-sensing system Escherichia coli
Online pristup:	http://link.springer.com/article/10.1186/s13068-019-1438-3
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!