Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

Abstract Background 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory...

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Үндсэн зохиолчид:	Yu-Ping Shen, Lai San Fong, Zhi-Bo Yan, Jian-Zhong Liu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2019-04-01
Цуврал:	Biotechnology for Biofuels
Нөхцлүүд:	4-Hydroxyphenylacetic acid Directed evolution Dynamic pathway regulation Quorum-sensing system Escherichia coli
Онлайн хандалт:	http://link.springer.com/article/10.1186/s13068-019-1438-3
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!