Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

Abstract Background 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory...

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Autors principals:	Yu-Ping Shen, Lai San Fong, Zhi-Bo Yan, Jian-Zhong Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-04-01
Col·lecció:	Biotechnology for Biofuels
Matèries:	4-Hydroxyphenylacetic acid Directed evolution Dynamic pathway regulation Quorum-sensing system Escherichia coli
Accés en línia:	http://link.springer.com/article/10.1186/s13068-019-1438-3
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