Adjuvants influence the maturation of VRC01-like antibodies during immunization

Summary: Once naive B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. He...

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Detalles Bibliográficos

Principais autores:	Maria L. Knudsen, Parul Agrawal, Anna MacCamy, K. Rachael Parks, Matthew D. Gray, Brittany N. Takushi, Arineh Khechaduri, Kelsey R. Salladay, Rhea N. Coler, Celia C. LaBranche, David Montefiori, Leonidas Stamatatos
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2022-11-01
Series:	iScience
Assuntos:	Biological sciences Immune response Immunology Virology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S258900422201745X
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