Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

Summary: An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by vaccination. Several HIV-1 envelope-derived germlin...

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Autori principali:	Emilie Seydoux, Yu-Hsin Wan, Junli Feng, Abigail Wall, Safia Aljedani, Leah J. Homad, Anna J. MacCamy, Connor Weidle, Matthew D. Gray, Lauren Brumage, Justin J. Taylor, Marie Pancera, Leonidas Stamatatos, Andrew T. McGuire
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-05-01
Serie:	Cell Reports
Soggetti:	HIV-1 vaccines anti-idiotypic antibodies broadly neutralizing antibodies B cell receptor antibody light chain
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124721004174
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