A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design with a matrix-based approach to generate VRC0...

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Detalles Bibliográficos

Principais autores:	Young D. Kwon, Mangaiarkarasi Asokan, Jason Gorman, Baoshan Zhang, Qingbo Liu, Mark K. Louder, Bob C. Lin, Krisha McKee, Amarendra Pegu, Raffaello Verardi, Eun Sung Yang, VRC Production Program, Kevin Carlton, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2021-01-01
Series:	mAbs
Assuntos:	Antibody VRC01 broadly neutralizing antibody HIV-1 envelope trimer matrix-based design polyreactivity prophylaxis
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/19420862.2021.1946918
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