Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env. Immunogen design has mostly relied on glycan removal from...

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Bibliografiska uppgifter

Huvudupphov:	Andrew J Borst, Connor E Weidle, Matthew D Gray, Brandon Frenz, Joost Snijder, M Gordon Joyce, Ivelin S Georgiev, Guillaume BE Stewart-Jones, Peter D Kwong, Andrew T McGuire, Frank DiMaio, Leonidas Stamatatos, Marie Pancera, David Veesler
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	eLife Sciences Publications Ltd 2018-11-01
Serie:	eLife
Ämnen:	HIV HIV envelope VRC01 cryoEM crystallography glycan shield
Länkar:	https://elifesciences.org/articles/37688
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