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Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial–mesenchymal transition

AimTo investigate the inhibitory effect of luteolin on proliferative vitreoretinopathy (PVR) and explore its potential mechanism.MethodsHuman retinal pigment epithelial ARPE-19 cells were treated with luteolin (0–50 μM) to assess its effects on cell viability, migration, and TGF-β2–induced epithelia...

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Principais autores: Lingdan Wu, Meiling Chen, Jinghua Chai, Yujie Tang, Qihua Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Frontiers in Pharmacology
Assuntos:
proliferative vitreoretinopathy
epithelial-mesenchymal transition
retinal pigment epithelial cell
luteolin
TGF-β2
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1634617/full
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