Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial–mesenchymal transition

AimTo investigate the inhibitory effect of luteolin on proliferative vitreoretinopathy (PVR) and explore its potential mechanism.MethodsHuman retinal pigment epithelial ARPE-19 cells were treated with luteolin (0–50 μM) to assess its effects on cell viability, migration, and TGF-β2–induced epithelia...

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Hlavní autoři:	Lingdan Wu, Meiling Chen, Jinghua Chai, Yujie Tang, Qihua Xu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-02-01
Edice:	Frontiers in Pharmacology
Témata:	proliferative vitreoretinopathy epithelial-mesenchymal transition retinal pigment epithelial cell luteolin TGF-β2
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1634617/full
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