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Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis

Abstract Background Hematopoietic stem cells (HSCs) maintain blood production via tightly regulated differentiation. Disruptions at this level can lead to myelodysplastic syndromes (MDS), characterized by ineffective hematopoiesis and marrow failure. Despite its clinical use, the antihypertensive an...

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Principais autores: Xiaoling Shi, Yushi Liu, Lejun Huang, Yuxin Ou, Xinyu Chen, Yiming Ling, Yiyue Zhang, Qing Lin
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Cell Communication and Signaling
Fag:
Wnt4
Minoxidil
MDS
Online adgang:https://doi.org/10.1186/s12964-025-02615-z
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