Distribution of NUDT15*4 in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs

IntroductionTolerance to thiopurine drugs is modulated by polymorphisms in the TPMT and NUDT15 pharmacogenes, affecting the activity of the encoded TPMT and NUDT15 enzymes. A recent study disclosed a significant impact of the NUDT15 rs147390019 single nucleotide variant (SNV) on thiopurine tolerance...

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主要な著者:	Guilherme Suarez-Kurtz, Anna Beatriz Ribeiro Elias, Marcelo Alex Carvaho, Alessandra Dias, Leonor Gusmão, Paulo Cesar Basta, Jamila Alessandra Perini
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-03-01
シリーズ:	Frontiers in Pharmacology
主題:	genetic polymorphism indigenous people native ancestry personalized medicine pharmacogenes pharmacogenetic guideline
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1804744/full
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