Distribution of NUDT15*4 in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs

IntroductionTolerance to thiopurine drugs is modulated by polymorphisms in the TPMT and NUDT15 pharmacogenes, affecting the activity of the encoded TPMT and NUDT15 enzymes. A recent study disclosed a significant impact of the NUDT15 rs147390019 single nucleotide variant (SNV) on thiopurine tolerance...

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Egile Nagusiak:	Guilherme Suarez-Kurtz, Anna Beatriz Ribeiro Elias, Marcelo Alex Carvaho, Alessandra Dias, Leonor Gusmão, Paulo Cesar Basta, Jamila Alessandra Perini
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2026-03-01
Saila:	Frontiers in Pharmacology
Gaiak:	genetic polymorphism indigenous people native ancestry personalized medicine pharmacogenes pharmacogenetic guideline
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1804744/full
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