The Effect of <i>NUDT15</i>, <i>TPMT</i>, <i>APEX1</i>, and <i>ITPA</i> Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia
Mercaptopurine (MP) is a commonly used maintenance regimen for childhood acute lymphoblastic leukemia (ALL). However, 6-MP has a narrow therapeutic index, which causes dose-limiting toxicities in hematopoietic tissues. Recent studies reported several candidate pharmacogenetic markers such as TPMT, N...
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| Huvudupphov: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
MDPI AG
2021-03-01
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| Serie: | Children |
| Ämnen: | |
| Länkar: | https://www.mdpi.com/2227-9067/8/3/224 |
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