The Effect of <i>NUDT15</i>, <i>TPMT</i>, <i>APEX1</i>, and <i>ITPA</i> Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia

Mercaptopurine (MP) is a commonly used maintenance regimen for childhood acute lymphoblastic leukemia (ALL). However, 6-MP has a narrow therapeutic index, which causes dose-limiting toxicities in hematopoietic tissues. Recent studies reported several candidate pharmacogenetic markers such as TPMT, N...

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Autori principali:	Jae Min Lee, Ye Jee Shim, Do-Hoon Kim, Nani Jung, Jung-Sook Ha
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-03-01
Serie:	Children
Soggetti:	6-mercaptopurine acute lymphoblastic leukemia <i>TPMT</i> <i>NUDT15</i> <i>ITPA</i> <i>APEX</i>
Accesso online:	https://www.mdpi.com/2227-9067/8/3/224
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