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Integrating single-cell RNA-seq and bulk RNA-seq to identify hub pathways and diagnostic biomarkers in active pulmonary tuberculosis

Abstract Background Tuberculosis (TB) continues to be a major global health challenge, with difficulties in distinguishing active TB (ATB) from latent TB infection (LTBI) and identifying early biomarkers for diagnosis. Methods This study integrated single-cell RNA sequencing (scRNA-seq) and bulk tra...

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Main Authors: Yanling Wei, Lin Sun, Hongqiu Pan, Yifan Zhong, Hongyu Chen, Jianming Wang
Format: Artigo
Language:Inglês
Published: BMC 2026-02-01
Series:BMC Infectious Diseases
Subjects:
Tuberculosis
scRNA-seq
bulk RNA-seq
Monocytes
Transcriptional biomarkers
Online Access:https://doi.org/10.1186/s12879-026-12805-w
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