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B-cell signatures characterize the immune landscape and predict LUAD prognosis via the integration of scRNA-seq and bulk RNA-seq

Abstract Lung adenocarcinoma (LUAD) is the most common type of lung cancer, accounting for approximately 35–40% of lung cancers, and the overall survival time of patients with LUAD is still very poor. B cells are important effector cells of adaptive immunity, and B-cell infiltration increases in var...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kexin Xu, Di Han, Zhengyuan Fan, Ya Li, Suxiao Liu, Yixi Liao, Hua Zhou, Qibiao Wu, Suyun Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-02-01
Schriftenreihe:Scientific Reports
Schlagworte:
B cell
Lung adenocarcinoma
ScRNA-seq
Bulk RNA-seq
Prognostic risk model
Immunotherapy
Online-Zugang:https://doi.org/10.1038/s41598-025-89213-8
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