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Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

The most advanced malaria vaccine, RTS,S, includes the central repeat and C-terminal domains of the <i>Plasmodium falciparum</i> circumsporozoite protein (PfCSP). We have recently isolated human antibodies that target the junctional region between the N-terminal and repeat domains that are not inclu...

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Gardado en:
Principais autores: Joseph R. Francica, Wei Shi, Gwo-Yu Chuang, Steven J. Chen, Lais Da Silva Pereira, S. Katie Farney, Barbara J. Flynn, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Lawrence T. Wang, Alexander Anderson, Zoltan Beck, Marlon Dillon, Azza H. Idris, Nicholas Hurlburt, Tracy Liu, Baoshan Zhang, Carl R. Alving, Gary R. Matyas, Marie Pancera, John R. Mascola, Peter D. Kwong, Robert A. Seder
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-03-01
Series:Vaccines
Assuntos:
junctional epitope
malaria
neutralizing antibodies
parasite
<i>Plasmodium falciparum</i>
vaccines
Acceso en liña:https://www.mdpi.com/2076-393X/9/3/272
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