Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses

Abstract Background Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disorder with an increasing incidence rate. Despite advances in ALS research over the years, the precise etiology and pathogenic mechanisms remain largely elusive. Objective To identify novel plasma prote...

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Autores principales:	Chuan Lu, Xiao-xiao Huang, Ming Huang, Chaoning Liu, Jianwen Xu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-03-01
Colección:	BMC Neurology
Materias:	Amyotrophic lateral sclerosis Plasma proteins Mendelian randomization GO functional analysis KEGG pathway analysis Drug target prediction
Acceso en línea:	https://doi.org/10.1186/s12883-025-04091-x
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