Genetic effects of circulating hormone and proteome on amyotrophic lateral sclerosis identified by Mendelian randomization

Abstract Altered circulating hormones in ALS patients have been widely reported by previous observational studies, but whether these relationships are causal is unclear. Moreover, the potential therapeutic targets for ALS and the effects of plasma protein fluctuation on ALS progression are not fully...

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Detalhes bibliográficos

Principais autores:	Xinyue Fan, Yinting Zeng, Feifei Zhang, Yang Xu, Qixuan Duan, Shuting Long, Yumeng Lin, Kai Wang, Li Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-03-01
coleção:	Scientific Reports
Assuntos:	Amyotrophic lateral sclerosis Hormone Free testosterone Proteome Cytokine Inflammation
Acesso em linha:	https://doi.org/10.1038/s41598-025-95151-2
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