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α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Abstract Background Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). However, the mechanisms by which intracellular aSYN pathology contributes to dysfunction and degeneration of neurons in the brain are still unclear. A potentially relevant...

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Main Authors: Fanni F. Geibl, Martin T. Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L. Wokosin, Elena Nasiri, Constantin A. Grotmann, Valina L. Dawson, Ted M. Dawson, Navdeep S. Chandel, Wolfgang H. Oertel, D. James Surmeier
Format: Artigo
Language:Inglês
Published: BMC 2024-10-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Alpha-synuclein
Mitochondria
Substantia Nigra
Dopaminergic
Pedunculopontine nucleus
Online Access:https://doi.org/10.1186/s13024-024-00756-2
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