α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

Abstract Background Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). However, the mechanisms by which intracellular aSYN pathology contributes to dysfunction and degeneration of neurons in the brain are still unclear. A potentially relevant...

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Principais autores:	Fanni F. Geibl, Martin T. Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L. Wokosin, Elena Nasiri, Constantin A. Grotmann, Valina L. Dawson, Ted M. Dawson, Navdeep S. Chandel, Wolfgang H. Oertel, D. James Surmeier
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-10-01
Series:	Molecular Neurodegeneration
Assuntos:	Parkinson’s disease Alpha-synuclein Mitochondria Substantia Nigra Dopaminergic Pedunculopontine nucleus
Acceso en liña:	https://doi.org/10.1186/s13024-024-00756-2
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