The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes

Abstract Maternal protein homeostasis and timely degradation of maternal mRNAs are essential for meiotic cell-cycle progression and subsequent embryonic development, but the mechanisms of maternal protein degradation are poorly understood. Here, we show that KLHL8, a substrate adaptor of Cullin-RING...

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Hauptverfasser:	Huizhen Fan, Ruyi Liu, Ran Yu, Biaobang Chen, Qiaoli Li, Jian Mu, Weijie Wang, Tianyu Wu, Lin He, Lei Wang, Qing Sang, Zhihua Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2025-07-01
Schriftenreihe:	EMBO Reports
Schlagworte:	KLHL8 Ubiquitination Oocyte Maturation ZAR1 Maternal mRNA Decay
Online-Zugang:	https://doi.org/10.1038/s44319-025-00537-y
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