An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers

Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved in the tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation in diverse cancers remain to be elucidated. And there is currently no clinically feasible...

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Bibliografski detalji

Glavni autori:	Chungen Lan, Bo Ni, Tiansuo Zhao, Zekun Li, Junjin Wang, Ying Ma, Weidong Li, Xiuchao Wang
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-05-01
Serija:	Frontiers in Genetics
Teme:	YAP pan-cancer Skp2 proliferation drug sensitivity MLN4924
Online pristup:	https://www.frontiersin.org/articles/10.3389/fgene.2022.866702/full
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