An Integrative Pan-Cancer Analysis Revealing MLN4924 (Pevonedistat) as a Potential Therapeutic Agent Targeting Skp2 in YAP-Driven Cancers

Background: YAP, coded by YAP1 gene, is critical in the Hippo pathway. It has been reported to be involved in the tumorigenesis and progression of several cancers. However, its roles on tumor cell proliferation in diverse cancers remain to be elucidated. And there is currently no clinically feasible...

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Κύριοι συγγραφείς:	Chungen Lan, Bo Ni, Tiansuo Zhao, Zekun Li, Junjin Wang, Ying Ma, Weidong Li, Xiuchao Wang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2022-05-01
Σειρά:	Frontiers in Genetics
Θέματα:	YAP pan-cancer Skp2 proliferation drug sensitivity MLN4924
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fgene.2022.866702/full
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