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Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML

Summary: Despite recent advances in the understanding of the genomic landscape of pediatric acute myeloid leukemia (pedAML), targeted treatments are only available for selected genomic alterations, and the functional link between genotype and outcome remains partially elusive. Functional precision m...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Ben Haladik, Margarita Maurer-Granofszky, Peter Zoescher, Raul Jimenez-Heredia, Alexandra Frohne, Anna Segarra-Roca, Chloe Casey, Felix Kartnig, Sarah Giuliani, Christina Rashkova, Peter Repiscak, Michael N. Dworzak, Giulio Superti-Furga, Kaan Boztug
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2025-09-01
Rangatū:Cell Reports Medicine
Ngā marau:
pediatric AML
precision medicine
drug screening
high-content imaging
deep learning
data integration
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2666379125003775
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