Image-based drug screening combined with molecular profiling identifies signatures and drivers of therapy resistance in pediatric AML

Summary: Despite recent advances in the understanding of the genomic landscape of pediatric acute myeloid leukemia (pedAML), targeted treatments are only available for selected genomic alterations, and the functional link between genotype and outcome remains partially elusive. Functional precision m...

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Detalhes bibliográficos

Principais autores:	Ben Haladik, Margarita Maurer-Granofszky, Peter Zoescher, Raul Jimenez-Heredia, Alexandra Frohne, Anna Segarra-Roca, Chloe Casey, Felix Kartnig, Sarah Giuliani, Christina Rashkova, Peter Repiscak, Michael N. Dworzak, Giulio Superti-Furga, Kaan Boztug
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
Colecção:	Cell Reports Medicine
Assuntos:	pediatric AML precision medicine drug screening high-content imaging deep learning data integration
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666379125003775
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