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Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine

Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been reported to induce trained immunity in mice. Therefore,...

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Auteurs principaux: Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, Joseph Keane, Sharee A. Basdeo
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2023-01-01
Collection:The Journal of Clinical Investigation
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Accès en ligne:https://doi.org/10.1172/JCI162581
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