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Branched‐chain α‐keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity

Abstract Objectives Insulin resistance (IR) in adolescents with obesity is associated with a sex‐dependent metabolic ‘signature’ comprising the branched‐chain amino acids (BCAAs), glutamate/glutamine, C3/C5 acylcarnitines and uric acid. Here, we compared the levels of branched‐chain α‐keto acids (BC...

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Autori principali: Pinar Gumus Balikcioglu, Catherine Jachthuber Trub, Metin Balikcioglu, Olga Ilkayeva, Phillip J. White, Michael Muehlbauer, James R. Bain, Sarah Armstrong, Michael Freemark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2023-01-01
Serie:Endocrinology, Diabetes & Metabolism
Soggetti:
branched‐chain amino acid
branched‐chain α‐keto acid
childhood obesity
insulin resistance
metabolomics
Accesso online:https://doi.org/10.1002/edm2.388
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