Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism

Aims/hypothesisSodium–glucose cotransporter 2 inhibitors (SGLT2i) confer cardio-renal protection, and recent work implicates enhanced branched-chain amino acid (BCAA) catabolism as a potential mechanism in the heart. Whether SGLT2i also promotes renal BCAA catabolism is largely unknown. We hypothesi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Moeko Sakamoto, Nao Hasuzawa, Lixiang Wang, Kyoko Tashiro, Miyuki Kitamura, Shimpei Iwata, Nobuhiko Wada, Seiji Nomura, Sawako Moriyama, Mizuki Gobaru, Yukihiro Inoguchi, Ayako Nagayama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-11-01
Schriftenreihe:	Frontiers in Endocrinology
Schlagworte:	branched-chain amino acids (BCAA) SGLT2 inhibitors type 2 diabetes diabetic kidney disease renal BCAA metabolism urinary BCAA metabolites
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1706838/full
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