Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism

Aims/hypothesisSodium–glucose cotransporter 2 inhibitors (SGLT2i) confer cardio-renal protection, and recent work implicates enhanced branched-chain amino acid (BCAA) catabolism as a potential mechanism in the heart. Whether SGLT2i also promotes renal BCAA catabolism is largely unknown. We hypothesi...

Descripción completa

Detalles Bibliográficos

Autores principales:	Moeko Sakamoto, Nao Hasuzawa, Lixiang Wang, Kyoko Tashiro, Miyuki Kitamura, Shimpei Iwata, Nobuhiko Wada, Seiji Nomura, Sawako Moriyama, Mizuki Gobaru, Yukihiro Inoguchi, Ayako Nagayama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2025-11-01
Colección:	Frontiers in Endocrinology
Materias:	branched-chain amino acids (BCAA) SGLT2 inhibitors type 2 diabetes diabetic kidney disease renal BCAA metabolism urinary BCAA metabolites
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1706838/full
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!